Korean Journal of Nephrology 2008;27(1):133-136.
A Case of Primary Amyloidosis with Nephrotic Syndrome and Factor X Deficiency
Min Young Kim, M.D., Soo-Yeong Kwak, M.D., Kyung Hee Kim, M.D. Ji In Lee, M.D., Young Eun Ha, M.D., Dae-Joong Kim, M.D. Ha-Young Oh, M.D., Jung-Eun Lee, M.D., Woo Seong Huh, M.D. and Yoon-Goo Kim, M.D.
Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Korea
증례 : 콩팥 증후군과 혈액 응고인자 X 결핍을 보인 일차성 아밀로이드증 1예
김민영•곽수영•김경희•이지인•하영은•김대중•오하영•이정은•허우성•김윤구
성균관 대학교 의과대학교 삼성서울병원 내과
Abstract
We report a case of nephrotic syndrome and factor X deficiency secondary to primary amyloidosis. A 58-year-old man was referred to our hospital for evaluation of nephrotic syndrome and bleeding tendency. He was confirmed to have primary amyloidosis by renal biopsy, immunofixation electrophoresis and bone marrow findings. His bleeding tendency was due to prothrombin time prolongation caused by isolated factor X deficiency. If any patient with nephrotic syndrome has bleeding tendency due to coagulation abnormalities, that patient should be considered to have factor X deficiency secondary to primary amyloidosis.
Key Words: Factor X deficiency, Nephrotic syndrome, Amyloidosis


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